Mathematical Modelling

Several partners in the Centre have been involved in the last few years in developing mathematical models of separation processes in bioengineering systems of importance to industrial biotechnology. Liquid chromatography for protein separation is one of the most used operations in the industry. The advantage of having rigorously formulated mathematical models of protein separation through liquid chromatography and software development for simulation is that optimal conditions for a given case can be obtained at a lower cost due to a reduction in experimental work, especially for recombinant proteins expressed by well-known hosts such as E.coliand S.cerevisiae.

Transporters and iron absorption regulation: one of our goals is the understanding of iron transport phenomena associated with intestinal iron absorption through mathematical modeling. The aim is to use a systems biology strategy, where a mathematical framework is established to study the complexity of biological systems arising from the interplay of transport processes, metabolism, regulation and control processes. Mathematical models of tumor growth: another goal considers the importance of cancer worldwide and in particular in Chile. Clear evidence shows that it is necessary to address strategies to study and control this disease. We aim to understand the effectiveness of new drugs that fight against the angiogenesis process, along with mixed therapies that include traditional cancer treatments.

Technological strategy to be involved in applied research with impact in industry: the development of collaborative projects with industrial partners in which the understanding and application of mathematical models in which biomechanics and mechanics is relevant will be also a priority. Given our national reality, some of our collaborations are centered on aspects of the copper mining industry. The areas of interest include the extraction of the mineral and its refinement using different techniques (for example, bio-leaching). Research and development strategy to be involved in innovation: puncture procedures are extensively used in medicine for catheterization and diagnosis and treatment.

The objective of this research and development project is to design and assemble an ultrasonic-assisted puncture device, which is ultra-portable and cost-effective, based on high computational efficiency Doppler ultrasound techniques.